Fig. 4. TRPM2 downregulation is associated with an increase in intracellular ROS and NOS levels. (A & B) Representative histograms and bar graphs of intracellular ROS level in lung cancer scramble cells and TRPM2-KD cells (C & D) Mitochondrial ROS production level in A549 and H1299 cells before and after TRPM2 depletion (E & F) The level of accumulated Nitric Oxide in TRPM2-KD cells in compare to wildtype lung cancer cells (t test vs scr. ***, p<0.001; **, p<0.01; * p<0.05).